1. Departments of Pharmacology (V.S., B.M.O., S.A.K., D.J.M.), University of Texas Southwestern Medical Center, Dallas, Texas 75390;
2. Departments of Internal Medicine and Pharmacology (J.L., R.J.A.), University of Michigan, Ann Arbor, Michigan 48109;
3. the Michigan Metabolomics and Obesity Center (R.C.), University of Michigan, Ann Arbor, Michigan 48109;
4. Molecular Biology (S.A.K.), University of Texas Southwestern Medical Center, Dallas, Texas 75390;
5. the Institute of Metabolism and Systems Research (B.A.H., W.A.), University of Birmingham, Birmingham B15 2TT, United Kingdom
6. the Howard Hughes Medical Institute (D.J.M.), University of Texas Southwestern Medical Center, Dallas, Texas 75390;