Sex-specific Association Between Adipose Tissue Inflammation and Vascular and Metabolic Complications of Obesity

Author:

Cossins Benjamin C1,van den Munckhof Inge1,Rutten Joost H W1,van der Graaf Marinette2,Stienstra Rinke13,Joosten Leo A B14,Netea Mihai G15,Li Yang16,Riksen Niels P1ORCID

Affiliation:

1. Department of Internal Medicine & Radboud Institute for Molecular Life Sciences (RIMLS), Radboud University Medical Center , 6525 GA Nijmegen , the Netherlands

2. Department of Medical Imaging, Radboud University Medical Center , 6525 GA Nijmegen , the Netherlands

3. Division of Human Nutrition and Health, Wageningen University & Research , 6708 WE Wageningen , the Netherlands

4. Department of Medical Genetics, Iuliu Haţieganu University of Medicine and Pharmacy , 400000 Cluj-Napoca , Romania

5. Department for Immunology and Metabolism, Life and Medical Sciences Institute (LIMES), University of Bonn , 53127 Bonn , Germany

6. Department of Computational Biology for Individualised Medicine, Centre for Individualised Infection Medicine (CiiM) & TWINCORE, joint ventures between the Helmholtz-Centre for Infection Research (HZI) and the Hannover Medical School (MHH) , 30625 Hannover , Germany

Abstract

Abstract Context Adipose tissue (AT) inflammation predisposes to insulin resistance and metabolic syndrome in obesity. Objective To investigate the association between adipocyte size, AT inflammation, systemic inflammation, and metabolic and atherosclerotic complications of obesity in a sex-specific manner. Design Cross-sectional cohort study. Setting University hospital in the Netherlands. Participants A total of 302 adult subjects with a body mass index (BMI) ≥ 27 kg/m2. Main outcome measures We obtained subcutaneous abdominal fat biopsies and systematically assessed, in a sex-specific manner, associations of several parameters of AT inflammation (including adipocyte size, macrophage content, crown-like structures, and gene expression) to biomarkers of systemic inflammation, leukocyte number and function, and to the presence of metabolic syndrome, insulin resistance, and carotid atherosclerotic plaques, assessed with ultrasound. Results Adipocyte size was associated with metabolic syndrome and AT macrophage content with insulin resistance. In contrast, none of the AT parameters was associated with carotid atherosclerosis, although mRNA expression of the anti-inflammatory IL-37 was associated with a lower intima-media thickness. We revealed profound sex-specific differences, with an association between BMI and adipocyte size, and between adipocyte size and metabolic syndrome in men only. Also, only men showed an association between adipocyte size, AT expression of leptin and MCP-1, and AT macrophage numbers, and between AT inflammation (crown-like structure number) and several circulating inflammatory proteins, including high specificity C-reactive protein, and IL-6. Conclusions Inflammation in abdominal subcutaneous adipose tissue is more related to the metabolic than the atherosclerotic complications of obesity, and there are profound sex-specific differences in the association between BMI, adipocyte size, AT inflammation, and systemic inflammation, which are much stronger in men than women.

Funder

CVON

European Research Area Network on Cardiovascular Diseases

Dutch Heart Foundation

European Research Council

Spinoza Prize

ZonMw

Dutch Diabetes Foundation

Competitiveness Operation Program

Romanian Ministry of European Funds

Publisher

The Endocrine Society

Subject

Biochemistry (medical),Clinical Biochemistry,Endocrinology,Biochemistry,Endocrinology, Diabetes and Metabolism

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3