Association of Gestational Free and Total Triiodothyronine With Gestational Hypertension, Preeclampsia, Preterm Birth, and Birth Weight: An Individual Participant Data Meta-analysis-Reference-Cited by-同舟云学术

Association of Gestational Free and Total Triiodothyronine With Gestational Hypertension, Preeclampsia, Preterm Birth, and Birth Weight: An Individual Participant Data Meta-analysis

Published:2023-10-25 Issue: Volume: Page:
ISSN:0021-972X
Container-title:The Journal of Clinical Endocrinology & Metabolism
language:en
Short-container-title:

Author:

Derakhshan Arash¹²^ORCID,Männistö Tuija³,Chen Liangmiao⁴,Osinga Joris A J¹²,Ashoor Ghalia⁵,Lu Xuemian⁴,Bliddal Sofie⁶⁷^ORCID,Tao Fang-Biao⁸⁹,Brown Suzanne J¹⁰,Vaidya Bijay¹¹,Hattersley Andrew T¹²,Itoh Sachiko¹³,Popova Polina V¹⁴¹⁵,Aminorroaya Ashraf¹⁶,Kishi Reiko¹³,Kianpour Maryam¹⁶,Vasukova Elena A¹⁴,López-Bermejo Abel¹⁷¹⁸^ORCID,Oken Emily¹⁹^ORCID,Chatzi Leda²⁰,Vafeiadi Marina²¹,Bramer Wichor M²²^ORCID,Bassols Judit²³,Lertxundi Aitana²⁴²⁵²⁶,Fernández-Somoano Ana²⁴²⁷²⁸,Carrasco Paula²⁹³⁰,Auvinen Juha³¹,Huang Kun³²³³,Feldt-Rasmussen Ulla⁶⁷^ORCID,Grineva Elena N¹⁴,Alexander Erik K³⁴,Pearce Elizabeth N³⁵^ORCID,Chaker Layal¹²,Walsh John P¹⁰³⁶,Peeters Robin P¹²^ORCID,Guxens Mònica²⁴³⁷³⁸³⁹,Suvanto Eila⁴⁰,Nicolaides Kypros H⁴¹,Korevaar Tim I M¹²

Affiliation:

1. Department of Internal Medicine, Erasmus University Medical Center , Rotterdam 3015 GD , The Netherlands

2. Academic Center for Thyroid Diseases, Erasmus University Medical Center , Rotterdam 3015 GD , The Netherlands

3. Northern Finland Laboratory Center Nordlab and Medical Research Center Oulu, Oulu University Hospital and University of Oulu , Oulu 90570 , Finland

4. Department of Endocrinology and Rui'an Center of the Chinese-American Research Institute for Diabetic Complications, Third Affiliated Hospital of Wenzhou Medical University , Wenzhou 325035 , China

5. Harris Birthright Research Center for Fetal Medicine, King’s College Hospital , London SE5 9RS , UK

6. Department of Medical Endocrinology and Metabolism, Copenhagen University Hospital, Rigshospitalet , Copenhagen 2100 , Denmark

7. Department of Clinical Medicine, Faculty of Health and Clinical Sciences, Copenhagen University , Copenhagen 1172 , Denmark

8. Department of Maternal, Child and Adolescent Health, School of Public Health, Anhui Medical University , Hefei, Anhui 230032 , China

9. Anhui Provincial Key Laboratory of Population Health & Aristogenics , Hefei, Anhui 230032 , China

10. Department of Endocrinology and Diabetes, Sir Charles Gairdner Hospital , Nedlands 6009, Perth, Western Australia , Australia

11. Department of Endocrinology, Royal Devon University Hospital NHS Foundation Trust, University of Exeter Medical School , Exeter EX1 2LU , UK

12. Institute of Biomedical and Clinical Science, University of Exeter Medical School , Exeter EX1 2LU , UK

13. Center for Environmental and Health Sciences, Hokkaido University , Sapporo, Hokkaido 060-0808 , Japan

14. World-Class Research Center for Personalized Medicine and institute of Endocrinology, Almazov National Medical Research Centre , Saint Petersburg 197341 , Russia

15. Department of Internal Diseases and Endocrinology, St. Petersburg Pavlov State Medical University , Saint Petersburg 197341 , Russian Federation

16. Isfahan Endocrine and Metabolism Research Center, Isfahan University of Medical Sciences , Isfahan 81745-33871 , Iran

17. Pediatric Endocrinology Research Group, Girona Biomedical Research Institute (IDIBGI) & Dr. Josep Trueta Hospital , Girona 17007 , Spain

18. Departament de Ciències Mèdiques, Universitat de Girona , Girona 17007 , Spain

19. Division of Chronic Disease Research Across the Lifecourse, Department of Population Medicine, Harvard Medical School , Boston, MA 02215 , USA

20. Department of Population and Public Health Sciences UoSC, Keck School of Medicine , Los Angeles, CA 90033 , USA

21. Department of Social Medicine, School of Medicine, University of Crete , Heraklion 700 13, Crete , Greece

22. Medical Library, Erasmus University Medical Centre , GD Rotterdam 3015 , The Netherlands

23. Maternal-Fetal Metabolic Research Group, Girona Biomedical Research Institute (IDIBGI), Dr. Josep Trueta Hospital , Girona 17007 , Spain

24. Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Instituto de Salud Carlos III , Madrid 28029 , Spain

25. Department of Preventive Medicine and Public Health, University of Basque Country , Leioa 48940 , Spain

26. BIODONOSTIA Health Research Institute , San Sebastian 20014 , Spain

27. Unit of Molecular Cancer Epidemiology, University Institute of Oncology of the Principality of Asturias (IUOPA)–Department of Medicine, University of Oviedo , Oviedo 33006, Asturias , Spain

28. Institute of Health Research of the Principality of Asturias (ISPA) , Oviedo 33006 , Spain

29. Epidemiology and Environmental Health Joint Research Unit, FISABIO−Universitat Jaume I−Universitat de València , Valencia 46020 , Spain

30. Department of Medicine, Universitat Jaume I , Castellón de la Plana 12071 , Spain

31. Medical Research Center Oulu, Oulu University Hospital, and Center for Life Course Health Research, University of Oulu , Oulu 90570 , Finland

32. Department of Maternal, Child and Adolescent Health, School of Public Health, Anhui Medical University , Anhui 230032 , China

33. Scientific Research Center in Preventive Medicine, School of Public Health, Anhui Medical University , Anhui 230032 , China

34. Division of Endocrinology, Hypertension and Diabetes, Brigham and Women’s Hospital, Harvard Medical School , Boston, MA 02215 , USA

35. Section of Endocrinology, Diabetes, and Nutrition, Boston University School of Medicine , Boston, MA 02215 , USA

36. Medical School, University of Western Australia , Crawley, WA 6009 , Australia

37. ISGlobal , Barcelona 08003 , Spain

38. Pompeu Fabra University , Barcelona 08002 , Spain

39. Department of Child and Adolescent Psychiatry/Psychology, Erasmus University Medical Centre–Sophia Children’s Hospital , GD Rotterdam 3012 , The Netherlands

40. Department of Obstetrics and Gynecology and Medical Research Center Oulu, University of Oulu , Oulu 90570 , Finland

41. Department of Women and Children’s Health, Faculty of Life Sciences and Medicine King’s College London , London WC2R 2LS , UK

Abstract

Abstract Context Triiodothyronine (T3) is the bioactive form of thyroid hormone. In contrast to thyroid-stimulating hormone and free thyroxine, we lack knowledge on the association of gestational T3 with adverse obstetric outcomes. Objective To investigate the associaiton of gestational free or total T3 (FT3 or TT3) with adverse obstetric outcomes. Methods We collected individual participant data from prospective cohort studies on gestational FT3 or TT3, adverse obstetric outcomes (preeclampsia, gestational hypertension, preterm birth and very preterm birth, small for gestational age [SGA], and large for gestational age [LGA]), and potential confounders. We used mixed-effects regression models adjusting for potential confounders. Results The final study population comprised 33 118 mother–child pairs of which 27 331 had data on FT3 and 16 164 on TT3. There was a U-shaped association of FT3 with preeclampsia (P = .0069) and a J-shaped association with the risk of gestational hypertension (P = .029). Higher TT3 was associated with a higher risk of gestational hypertension (OR per SD of TT3 1.20, 95% CI 1.08 to 1.33; P = .0007). A lower TT3 but not FT3 was associated with a higher risk of very preterm birth (OR 0.72, 95% CI 0.55 to 0.94; P = .018). TT3 but not FT3 was positively associated with birth weight (mean difference per 1 SD increase in TT3 12.8, 95% CI 6.5 to 19.1 g, P < .0001) but there was no association with SGA or LGA. Conclusion This study provides new insights on the association of gestational FT3 and TT3 with major adverse pregnancy outcomes that form the basis for future studies required to elucidate the effects of thyroid function on pregnancy outcomes. Based on the current study, routine FT3 or TT3 measurements for the assessment of thyroid function during pregnancy do not seem to be of added value in the risk assessment for adverse outcomes.

Funder

Netherlands Organization for Scientific Research

Publisher

The Endocrine Society

Subject

Biochemistry (medical),Clinical Biochemistry,Endocrinology,Biochemistry,Endocrinology, Diabetes and Metabolism

Link

https://academic.oup.com/jcem/advance-article-pdf/doi/10.1210/clinem/dgad631/53406282/dgad631.pdf

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