Improved HbA1c and Body Weight in GADA-Positive Individuals Treated With Tirzepatide: A Post Hoc Analysis of SURPASS

Author:

Peters Anne L1,Buzzetti Raffaella2,Lee Clare J3ORCID,Pavo Imre3,Liu Minzhi4,Karanikas Chrisanthi A3,Paik Jim S3

Affiliation:

1. University of Southern California Clinical Diabetes Program, Keck School of Medicine of the University of Southern California, Los Angeles , Los Angeles, CA 90033 , USA

2. Department of Experimental Medicine, Sapienza University of Rome , Rome 00160 , Italy

3. Eli Lilly and Company , Indianapolis, IN 46285 , USA

4. Tigermed-BCM Inc , Somerset, NJ 08873 , USA

Abstract

Abstract Context People with clinically diagnosed type 2 diabetes (T2D) but positive antiglutamic acid decarboxylase autoantibodies (GADA), referred to here as latent autoimmune diabetes in adults (LADA), may experience more rapid glycemic deterioration than those with T2D and may benefit from effective diabetes treatment with additional metabolic benefits. Objective This work aimed to assess glycated hemoglobin A1c (HbA1c) and body weight (BW) changes associated with tirzepatide in GADA-positive vs GADA-negative participants with a clinical T2D diagnosis. Methods Post hoc analyses based on pooled data from SURPASS 2-5, using mixed-model repeated measures from the efficacy analysis set, adjusting for study and baseline covariates including age, sex, baseline values, body mass index (BMI), and GADA status, were conducted on 3791 individuals. Intervention included tirzepatide (5, 10, 15 mg). Main outcome measure included change from baseline in HbA1c at weeks 40 (SURPASS-2, -3, -5) and 42 (SURPASS-4) by GADA status. Results In participants with confirmed GADA status, 3671 (96.8%) were GADA negative and 120 (3.2%) were GADA positive (76 [63.3%] with low and 44 [36.7%] with high GADA levels). Baseline characteristics were similar between groups, except for slightly lower BMI in GADA-positive vs GADA-negative participants (mean [SD] BMI 32.2 [6.1] vs 33.6 [6.3]). At week 40/42, both groups achieved robust reductions in HbA1c (−2.11% vs −2.32%) and BW (–9.2 kg vs −9.6 kg) (P < .001, both groups). HbA1c reductions were greater in GADA-negative participants (estimated difference [95% CI]: 0.21% [0.03, 0.39]; P = .024) and BW reductions did not differ between groups (0.38 kg [−0.99, 1.75]; P = .588). Conclusion In this post hoc analysis, tirzepatide was associated with substantial reductions in HbA1c and BW irrespective of GADA status in adults diagnosed with T2D, suggesting that tirzepatide may improve glycemic control in individuals with LADA.

Funder

Eli Lilly and Company

Publisher

The Endocrine Society

Cited by 1 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. GLP1R Agonists and Precision Medicine: In Search of Predictive Biomarkers;The Journal of Clinical Endocrinology & Metabolism;2024-08-07

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