A Low Protein Diet Alters the Balance of Islet Cell Replication and Apoptosis in the Fetal and Neonatal Rat and Is Associated with a Reduced Pancreatic Expression of Insulin-Like Growth Factor-II1

Author:

Petrik J.123,Reusens B.4,Arany E.15,Remacle C.4,Coelho C.12,Hoet J. J.254,Hill D. J.13

Affiliation:

1. Lawson Research Institute (J.P., E.A., C.C., D.J.H.), St. Joseph’s Health Centre, London, Ontario N6A 4V2, Canada

2. Departments of Physiology (J.P., C.C., D.J.H.), University of Western Ontario, London, Ontario N6A 5A5, Canada

3. Paediatrics (J.P., D.J.H.), University of Western Ontario, London, Ontario N6A 5A5, Canada

4. Laboratoire de Biologie Cellulaire (B.R., C.R., J.J.H.), World Health Organization Collaborating Centre for the Development of the Biology of the Endocrine Pancreas, Université Catholique de Louvain, B-1348 Louvain-La-Neuve, Belgium

5. Medicine (E.A., D.J.H.), University of Western Ontario, London, Ontario N6A 5A5, Canada

Publisher

The Endocrine Society

Subject

Endocrinology

Reference48 articles.

1. Type 2 (non-insulin-dependent) diabetes mellitus: the thrifty phenotype hypothesis.;Hales;Diabetologia,1992

2. Long-term consequences of diabetes and its complications may have a fetal origin: experimental and epidemiologial evidence. In: Cowett RM (ed) Diabetes.;Reusens;Nestlé Nutrition Workshop Series, Raven Press, New York, vol,1995

3. Effect of a low protein diet during pregnancy on the fetal rat endocrine pancreas.;Snoeck;Biol Neonate,1990

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