The Proinflammatory Cytokines Tumor Necrosis Factor-α and Interleukin-1 Stimulate Neuropeptide Gene Transcription and Secretion in Adrenochromaffin Cells via Activation of Extracellularly Regulated Kinase 1/2 and p38 Protein Kinases, and Activator Protein-1 Transcription Factors

Author:

Ait-Ali Djida1,Turquier Valerie1,Grumolato Luca1,Yon Laurent1,Jourdain Matthieu1,Alexandre David1,Eiden Lee E.2,Vaudry Hubert1,Anouar Youssef1

Affiliation:

1. Laboratory of Cellular and Molecular Neuroendocrinology (D.A.-A., V.T., L.G., L.Y., M. J., D.A., H.V., Y.A.), European Institute for Peptide Research (IFRMP 23), Institut National de la Santé et de la Recherche Médicale Unité 413, Unité Associée Centre National de la Recherche Scientifique, University of Rouen, 76821 Mont-Saint-Aignan, France

2. Section on Molecular Neuroscience (L.E.E.), Laboratory of Cellular and Molecular Regulation, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892

Publisher

The Endocrine Society

Subject

Endocrinology,Molecular Biology,General Medicine

Reference73 articles.

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2. Identification and topography of neuronal cell populations expressing TNF-α and IL-1 α in response to hippocampal lesion.;Tchelingerian;J Neurosci Res,1996

3. Human adrenal cells express tumor necrosis factor-α messenger ribonucleic acid: evidence for paracrine control of adrenal function.;Gonzalez-Hernandez;J Clin Endocrinol Metab,1996

4. Expression of surface lymphotoxin and tumor necrosis factor on activated T, B, and natural killer cells.;Ware;J Immunol,1992

5. The expression of tumor necrosis factor in human adipose tissue. Regulation by obesity, weight loss, and relationship to lipoprotein lipase.;Kern;J Clin Invest,1995

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