Chlorogenic acid improves diabetes-associated muscular atrophy in mice

Author:

liu xianchu,LIU MING

Abstract

Diabetes is closely relevant to muscle dysfunction. Chlorogenic acid (CGA) possesses various therapeutic functions in diabetic complications. However, no research implied the amelioration of CGA on diabetes-associated muscular atrophy. In this study, diabetic model was established by streptozotocin (STZ) to appraise roles of CGA (30 mg/kg/d for 8 weeks) on diabetes-associated muscular atrophy. Our researches demonstrated that CGA enhanced representative myocyte cross-sections, gastrocnemius weight and grip strength. In serum, CGA restricted CK, LDH, MDA, TNF-a and IL-6 levels, while elevated T-ACO, SOD and CAT levels against diabetic-evoked muscle damage. In skeletal muscle, CGA increased BCL-2 expression, while reduced FBXO-32, MURF-1, DDIT-3, GRP-87 and BAX expressions to improve diabetic muscular atrophy. In conclusion, CGA protected from diabetic-associated muscular atrophy through its bioactivities on the regulation of endoplasmic reticulum stress and apoptosis, and could be a powerful remedy approach in the ameliorations of diabetic muscle atrophy.

Publisher

Polish Pharmaceutical Society

Subject

Pharmaceutical Science,Pharmacology

全球学者库

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"全球学者库"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前全球学者库共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2023 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3