Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for Dihydropyrimidine Dehydrogenase Genotype and Fluoropyrimidine Dosing: 2017 Update

Author:

Amstutz Ursula1,Henricks Linda M.2,Offer Steven M.3,Barbarino Julia4,Schellens Jan H.M.25,Swen Jesse J.6,Klein Teri E.4,McLeod Howard L.7,Caudle Kelly E.8,Diasio Robert B.39,Schwab Matthias101112

Affiliation:

1. University Institute of Clinical Chemistry, Inselspital Bern University Hospital; University of Bern; Bern Switzerland

2. Department of Clinical Pharmacology, Division of Medical Oncology and Division of Pharmacology; the Netherlands Cancer Institute; Amsterdam the Netherlands

3. Department of Molecular Pharmacology and Experimental Therapeutics; Mayo Clinic; Rochester Minnesota USA

4. Department of Biomedical Data Science; Stanford University; Stanford California USA

5. Utrecht Institute for Pharmaceutical Sciences; Utrecht University; Utrecht the Netherlands

6. Department of Clinical Pharmacy & Toxicology; Leiden University Medical Center; Leiden the Netherlands

7. DeBartolo Family Personalized Medicine Institute and the Department of Population Sciences; H. Lee Moffitt Cancer Center & Research Institute; Tampa Florida USA

8. Department of Pharmaceutical Sciences; St. Jude Children's Research Hospital; Memphis Tennessee USA

9. Mayo Clinic Cancer Center; Mayo Clinic; Rochester Minnesota USA

10. Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology; Stuttgart Germany

11. Department of Clinical Pharmacology; University Hospital; Tuebingen Germany

12. Department of Pharmacy and Biochemistry; University of Tuebingen; Tuebingen Germany

Funder

National Institutes of Health

Robert Bosch Foundation

Publisher

Wiley

Subject

Pharmacology (medical),Pharmacology

Reference41 articles.

1. Clinical pharmacology of 5-fluorouracil;Diasio;Clin. Pharmacokinet.,1989

2. CPIC: Clinical Pharmacogenetics Implementation Consortium of the Pharmacogenomics Research Network;Relling;Clin. Pharmacol. Ther.,2011

3. Characterization of the human dihydropyrimidine dehydrogenase gene;Wei;Genomics,1998

4. CPIC CPIC ® Guideline for Fluoropyrimidines and DPYD https://cpicpgx.org/guidelines/guideline-for-fluoropyrimidines-and-dpyd/

5. Heterozygosity for a point mutation in an invariant splice donor site of dihydropyrimidine dehydrogenase and severe 5-fluorouracil related toxicity;Kuilenburg;Eur. J. Cancer,1997

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