Feeding tricarboxylic acid cycle intermediates improves lactate consumption and antibody production in Chinese hamster ovary cell cultures
Author:
Affiliation:
1. Biologics Process Research & Development, Process Research & DevelopmentMerck & Co., Inc. Kenilworth New Jersey
2. Biologics DevelopmentBristol‐Myers Squibb Co. Pennington 08534 NJ
Publisher
Wiley
Subject
Biotechnology
Link
https://onlinelibrary.wiley.com/doi/pdf/10.1002/btpr.2975
Reference36 articles.
1. Peak antibody production is associated with increased oxidative metabolism in an industrially relevant fed-batch CHO cell culture
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4. Metabolic signatures of GS-CHO cell clones associated with butyrate treatment and culture phase transition
5. Considerations on the lactate consumption by CHO cells in the presence of galactose
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