Proof of Concept: First Pediatric [ 14 C]microtracer Study to Create Metabolite Profiles of Midazolam-Reference-Cited by-同舟云学术

Proof of Concept: First Pediatric [ 14 C]microtracer Study to Create Metabolite Profiles of Midazolam

Published:2020-06-27 Issue:5 Volume:108 Page:1003-1009
ISSN:0009-9236
Container-title:Clinical Pharmacology & Therapeutics
language:en
Short-container-title:Clin. Pharmacol. Ther.

Author:

Groen Bianca D.¹,Duijn Esther²,Vries Arjan²,Mooij Miriam G.¹³⁴,Tibboel Dick¹,Vaes Wouter H. J.²,Wildt Saskia N.¹⁴

Affiliation:

1. Intensive Care and Department of Pediatric Surgery Erasmus Medical Center – Sophia Children’s Hospital Rotterdam The Netherlands

2. TNO Zeist The Netherlands

3. Department of Pediatrics Leiden University Medical Center Leiden The Netherlands

4. Department of Pharmacology and Toxicology Radboud University Nijmegen The Netherlands

Publisher

Wiley

Subject

Pharmacology (medical),Pharmacology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/cpt.1884

Reference42 articles.

1. Which Human Metabolites Have We MIST? Retrospective Analysis, Practical Aspects, and Perspectives For Metabolite Identification and Quantification in Pharmaceutical Development

2. International Conference on Harmonization.Guidance for industry: M3(R2) nonclinical safety studies for the conduct of human clinical trials and marketing authorization for pharmaceuticals (2010). Accessed June 14 2019.

3. Developmental Changes in Pharmacokinetics and Pharmacodynamics

4. Human Ontogeny of Drug Transporters: Review and Recommendations of the Pediatric Transporter Working Group

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