Multifunctional Amino Acid Derivative Coordination Compounds: Novel Contrast Agent and Luminescence Materials

Author:

Echenique‐Errandonea Estitxu1,Rojas Sara2,Ortuño Ana M.2,Cepeda Javier1,Ramos‐Cabrer Pedro3,Vitórica‐Yrezábal Íñigo J.2,Cuerva Juan M.2,Seco José M.1,Rodríguez‐Diéguez Antonio2

Affiliation:

1. Department of Applied Chemistry, Faculty of Chemistry University of Basque Country/Euskal Herriko Unibertsitatea (UPV/EHU) 20018 Donostia Spain

2. Department of Inorganic Chemistry University of Granada C/ Severo Ochoa s/n 18071 Granada Spain

3. Magnetic Resonance Imaging Laboratory CIC biomaGUNE 20014 Donostia-San Sebastián Spain

Abstract

AbstractIn this work a family of multidimensional (2‐(1H‐tetrazol‐5‐yl)ethyl) amino acid coordination compounds have been synthesized and thoroughly characterized. For this purpose, glycine, valine, phenylalanine and tyrosine have been selected as starting amino acids and Mn2+, Zn2+ and Cd2+ as metallic nodes. From one side, for Mn2+ based dimer magnetic resonance imaging studies have been conducted, prompted by the number and disposition of the coordinated water molecules and taking into consideration the promising future of manganese‐based coordination compounds as bio‐compatible substitutes to conventional Gd based contrast agents. From another side, d10 block metal‐based complexes allowed exploring photoluminescence properties derived by in situ synthesized ligands. Finally, amino acid preserved structural chirality allowed us to examine chiroptical properties, particularly focusing on circularly polarized luminescence.

Publisher

Wiley

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