Multicomponent Reaction: Pd/Cu‐Catalyzed Borocarbonylation of Aryldiazonium Salts with Aliphatic Terminal Alkynes to gem‐Bis(boryl) Ketones

Abstract

AbstractWe report the development of Pd/Cu‐catalyzed selective 2,1‐borocarbonylation reactions of aliphatic terminal alkynes with aryldiazonium salts and B2Pin2 to prepare gem‐bis(boryl) ketones in one‐pot. A series of corresponding products are obtained with good to excellent yields under a carbon monoxide atmosphere (10 bar). In addition, wide functional‐group tolerance can be observed. Preliminary mechanistic studies reveal that ethyl acetate serves as a proton source in the reaction.