Tumor Targeted Cuprous‐Based Nanocomposite as Responsive Cascade Nanocatalyst for Efficient Tumor Synergistic Therapy

Author:

Gao Weihua1,Zhang Jie2,Ding Lina1,Chang Yi2ORCID,Gao Fangli1,Yang Pengfei3,Ma Xiaoming3ORCID,Guo Yuming1ORCID

Affiliation:

1. School of Chemistry and Chemical Engineering Henan Normal University Xinxiang Henan 453007 China

2. Collaborative Innovation Center of Henan Province for Green Manufacturing of Fine Chemicals Henan Normal University Xinxiang Henan 453007 China

3. Key Laboratory of Green Chemical Media and Reactions Ministry of Education Henan Normal University Xinxiang Henan 453007 China

Abstract

AbstractThe single‐functionality of traditional chemodynamic therapy (CDT) reagents usually limits the therapeutic efficacy of cancer treatment. Synergistic nanocomposites that involve cascade reaction provide a promising strategy to achieve satisfactory anticancer effects. Herein, a cuprous‐based nanocomposite (CCS@GOx@HA) is fabricated, which owns the tumor targeting ability and can undergo tumor microenvironment responsive cascade reaction to enhance the tumor therapeutic efficiency significantly. Surface modification of nanocomposite with hyaluronic acid enables the targeted delivery of the nanocomposite to cancer cells. Acid‐triggered decomposition of nanocomposite in cancer cell results in the release of Cu+, Se2− and GOx. The Cu+ improves the Fenton‐like reaction with endogenous H2O2 to generate highly toxic • OH for CDT. While GOx can not only catalyze the in situ generation of endogenous H2O2, but also accelerate the consumption of intratumoral glucose to reduce nutrient supply in tumor site. In addition, Se2− further improves the therapeutic effects of CDT by upregulating the reactive oxygen species (ROS) in tumor cells. Meanwhile, the surface modification endows the nanocomposite the good water dispersibility and biocompatibility. Moreover, in vitro and in vivo experiments demonstrate satisfactory anti‐cancer therapeutic performance by the synergistic cascade function of CCS@GOx@HA than CDT alone.

Funder

National Natural Science Foundation of China

Natural Science Foundation of Henan Province

Science and Technology Innovation Talents in Universities of Henan Province

Overseas Expertise Introduction Project for Discipline Innovation

Publisher

Wiley

Subject

General Chemistry,Catalysis,Organic Chemistry

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