Affiliation:
1. School of Chemistry and Materials Science Jiangsu Normal University Xuzhou 221116 Jiangsu China
Abstract
AbstractAzecine fragments are frequently presented in natural products and bioactive compounds. However, minor efforts have been devoted to these 10‐membered N‐heterocycles, and their synthesis is still challenging. Reported herein is the first catalytic formal [6+4] cycloaddition for the synthesis of 10‐membered azecines. Under palladium catalysis, the reaction of δ‐vinylvalerolactones and benzofuran‐derived azadienes proceeds smoothly to afford benzofuran‐fused azecines with high diastereoselectivity in moderate to good yields. A unique transannular reaction of these 10‐membered azecines for the construction of polycyclic compounds is also demonstrated.
Funder
Science and Technology Support Program of Jiangsu Province
Subject
General Chemistry,Catalysis,Organic Chemistry