Diverse Synthesis of 2H‐Isoindole‐Based Polycyclic Aromatic Compounds

Abstract

Abstract1,3‐Disubstituted N‐aryl‐2H‐isoindoles have been synthesized by a cascade reaction of divinyl ethers, which are derived from easily available 4‐bromoisocoumarins, with substituted anilines in HFIP. This cascade reaction consists of a ring‐opening step through addition‐elimination mechanism and the following 5‐exo‐tet type ring‐closing step via the intramolecular nucleophilic substitution reaction. Thus obtained 2H‐isoindoles have been derivatized to high‐order nitrogen‐containing polycycles including less accessible benzo[a]ullazines.