Use of CE-SDS gel for characterization of monoclonal antibody hinge region clipping due to copper and high pH stress
Author:
Publisher
Wiley
Subject
Clinical Biochemistry,Biochemistry,Analytical Chemistry
Reference17 articles.
1. Specific cleavage of immunoglobulin G by copper ions
2. Non-enzymatic hinge region fragmentation of antibodies in solution
3. Optimization of a reversed-phase high-performance liquid chromatography/mass spectrometry method for characterizing recombinant antibody heterogeneity and stability
4. Characterization of the stability of a fully human monoclonal IgG after prolonged incubation at elevated temperature
5. β-Elimination and Peptide Bond Hydrolysis: Two Distinct Mechanisms of Human IgG1 Hinge Fragmentation upon Storage
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