The role of radiomics in tongue cancer: A new tool for prognosis prediction-Reference-Cited by-同舟云学术

The role of radiomics in tongue cancer: A new tool for prognosis prediction

Published:2023-02-13 Issue:4 Volume:45 Page:849-861
ISSN:1043-3074
Container-title:Head & Neck
language:en
Short-container-title:Head & Neck

Author:

Mossinelli Chiara¹,Tagliabue Marta¹²^ORCID,Ruju Francesca³,Cammarata Giulio⁴,Volpe Stefania⁵⁶^ORCID,Raimondi Sara⁴,Zaffaroni Mattia⁵,Isaksson Johannes Lars⁵,Garibaldi Cristina⁷,Cremonesi Marta⁷,Corso Federica⁴⁸⁹,Gaeta Aurora⁴,Emili Ilaria³¹⁰,Zorzi Stefano¹,Alterio Daniela⁵,Marvaso Giulia⁵⁶^ORCID,Pepa Matteo⁵,De Fiori Elvio³,Maffini Fausto¹¹,Preda Lorenzo¹²¹³,Benazzo Marco¹²¹⁴,Jereczek‐Fossa Barbara Alicja⁵⁶,Ansarin Mohssen¹^ORCID

Affiliation:

1. Department of Otorhinolaryngology and Head and Neck Surgery European Institute of Oncology, IRCCS Milan Italy

2. Department of Biomedical Sciences University of Sassari Sassari Italy

3. Division of Radiology IEO, European Institute of Oncology, IRCCS Milan Italy

4. Department of Experimental Oncology IEO European Institute of Experimental Oncology IRCCS Milan Italy

5. Division of Radiation Oncology European Institute of Oncology, IRCCS Milan Italy

6. Department of Oncology and Hemato‐Oncology University of Milan Milan Italy

7. Unit of Radiation Research IEO European Institute of Oncology, IRCCS Milan Italy

8. Department of Mathematics (DMAT) Politecnico di Milano Milan Italy

9. Centre for Health Data Science (CHDS) Human Techonopole

10. ASST Centro Specialistico Ortopedico Traumatologico G. Pini/C.T.O Milan Italy

11. Division of Pathology IEO, European Institute of Oncology, IRCCS Milan Italy

12. Department of Clinical, Surgical, Diagnostic, and Pediatric Sciences University of Pavia Pavia Italy

13. Division of Radiology Fondazione IRCCS Policlinico San Matteo Pavia Italy

14. Department of Otorhinolaryngology Fondazione IRCCS Policlinico San Matteo Pavia Italy

Abstract

AbstractBackgroundRadiomics represents an emerging field of precision‐medicine. Its application in head and neck is still at the beginning.MethodsRetrospective study about magnetic resonance imaging (MRI) based radiomics in oral tongue squamous cell carcinoma (OTSCC) surgically treated (2010–2019; 79 patients). All preoperative MRIs include different sequences (T1, T2, DWI, ADC). Tumor volume was manually segmented and exported to radiomic‐software, to perform feature extraction. Statistically significant variables were included in multivariable analysis and related to survival endpoints. Predictive models were elaborated (clinical, radiomic, clinical‐radiomic models) and compared using C‐index.ResultsIn almost all clinical‐radiomic models radiomic‐score maintained statistical significance. In all cases C‐index was higher in clinical‐radiomic models than in clinical ones. ADC provided the best fit to the models (C‐index 0.98, 0.86, 0.84 in loco‐regional recurrence, cause‐specific mortality, overall survival, respectively).ConclusionMRI‐based radiomics in OTSCC represents a promising noninvasive method of precision medicine, improving prognosis prediction before surgery.

Publisher

Wiley

Subject

Otorhinolaryngology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/hed.27299

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