The European Federation for Medicinal Chemistry (EFMC) Best Practice Initiative: Validating Chemical Probes-Reference-Cited by-同舟云学术

The European Federation for Medicinal Chemistry (EFMC) Best Practice Initiative: Validating Chemical Probes

Published:2020-09-03 Issue:24 Volume:15 Page:2388-2390
ISSN:1860-7179
Container-title:ChemMedChem
language:en
Short-container-title:ChemMedChem

Author:

Quancard Jean¹^ORCID,Cox Brian²^ORCID,Finsinger Dirk³,Guéret Stéphanie M.⁴^ORCID,Hartung Ingo V.³,Koolman Hannes F.⁵,Messinger Josef⁶,Sbardella Gianluca⁷^ORCID,Laufer Stefan⁸^ORCID

Affiliation:

1. Global Discovery Chemistry Novartis Institute For Biomedical Research Novartis Pharma AG Novartis Campus CH 4056 Basel. Switzerland

2. Professor of Pharmaceutical Chemistry School of Life Sciences University of Sussex Brighton BN1 9RH UK.

3. Medicinal Chemistry, Global R&D Merck Healthcare KGaA Frankfurter Straße 250 64293 Darmstadt Germany

4. Medicinal Chemistry Research and Early Development Cardiovascular Renal and Metabolism, BioPharmaceuticals R&D AstraZeneca Gothenburg Sweden

5. Medicinal chemistry, Boehringer Ingelheim Pharma GmbH & Co. KG Birkendorfer Straße 65 D 88397 Biberach an der Riss Germany

6. Global Medicine Design Orionpharma Orionintie 1 FI-02101 Espoo Finland

7. Department of Pharmacy Epigenetic Med Chem Lab University of Salerno Via Giovanni Paolo II 132 I-84084 Fisciano SA Italy

8. Pharmaceutical&Medicinal Chemistry Institute of Pharmacy&Biochemistry Tübingen Center for Academic Drug Discovery Auf der Morgenstelle 8 D 72070 Tuebingen Germany

Publisher

Wiley

Subject

Organic Chemistry,General Pharmacology, Toxicology and Pharmaceutics,Molecular Medicine,Drug Discovery,Biochemistry,Pharmacology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/cmdc.202000597

Reference16 articles.

1. The importance of triaging in determining the quality of output from high-throughput screening

2. https://www.efmc.info/best-practices.

3. https://www.chemicalprobes.org/faq.

4. Target validation using chemical probes

5. Target (In)Validation: A Critical, Sometimes Unheralded, Role of Modern Medicinal Chemistry

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