Pyrrole: A Decisive Scaffold for the Development of Therapeutic Agents and Structure‐Activity Relationship

Author:

Ganesh Bharathi Hassan12ORCID,Raj Anirudh G.1ORCID,Aruchamy Baladhandapani12ORCID,Nanjan Pandurangan13,Drago Carmelo4ORCID,Ramani Prasanna12ORCID

Affiliation:

1. Dhanvanthri Laboratory Department of Sciences Amrita School of Physical Sciences Coimbatore 641112, Amrita Vishwa Vidyapeetham India

2. Center of Excellence in Advanced Materials & Green Technologies (CoE–AMGT) Amrita School of Engineering Coimbatore 641112, Amrita Vishwa Vidyapeetham India

3. Amrita School of Engineering Coimbatore 641112, Amrita Vishwa Vidyapeetham India

4. Institute of Biomolecular Chemistry CNR via Paolo Gaifami 18 95126 Catania Italy

Abstract

AbstractAn overview of pyrroles as distinct scaffolds with therapeutic potential and the significance of pyrrole derivatives for drug development are provided in this article. It lists instances of naturally occurring pyrrole‐containing compounds and describes the sources of pyrroles in nature, including plants and microbes. It also explains the many conventional and modern synthetic methods used to produce pyrroles. The key topics are the biological characteristics, pharmacological behavior, and functional alterations displayed by pyrrole derivatives. It also details how pyrroles are used to treat infectious diseases. It describes infectious disorders resistant to standard treatments and discusses the function of compounds containing pyrroles in combating infectious diseases. Furthermore, the review covers the uses of pyrrole derivatives in treating non‐infectious diseases and resistance mechanisms in non‐infectious illnesses like cancer, diabetes, and Alzheimer's and Parkinson's diseases. The important discoveries and probable avenues for pyrrole research are finally summarized, along with their significance for medicinal chemists and drug development. A reference from the last two decades is included in this review.

Publisher

Wiley

Subject

Organic Chemistry,General Pharmacology, Toxicology and Pharmaceutics,Molecular Medicine,Drug Discovery,Biochemistry,Pharmacology

Reference247 articles.

1. Living on pyrrolic foundations – Advances in natural and artificial bioactive pyrrole derivatives

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