Affiliation:
1. Department of Chemistry Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials Fudan University Handan Road 220 Shanghai 200438 P. R. China
2. School of Pharmaceutical Engineering & Institute for Advanced Studies Taizhou University Shifu Avenue 1139 Jiaojiang Zhejiang 318000 P. R. China
Abstract
AbstractNew acyclic cucurbit[n]urils (ACBs) with eight carboxylate groups were synthesized. These hosts are highly soluble in water, and can form stable inclusion complexes with cationic bitter compounds. ACBs are confirmed to be non‐toxic and biocompatible. Two‐bottle preference (TBP) tests on mice show that all ACBs are tasteless to mammals. ACBs are discovered to mask the bitterness of berberine and denatonium benzoate, but not quinine hydrochloride, due to different binding modes.
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