Genome‐ and epigenome‐wide studies of plasma protein biomarkers for Alzheimer's disease implicate TBCA and TREM2 in disease risk-Reference-Cited by-同舟云学术

Genome‐ and epigenome‐wide studies of plasma protein biomarkers for Alzheimer's disease implicate TBCA and TREM2 in disease risk

Published:2022-01 Issue:1 Volume:14 Page:
ISSN:2352-8729
Container-title:Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
language:en
Short-container-title:Alz & Dem Diag Ass & Dis Mo

Author:

Hillary Robert F.¹^ORCID,Gadd Danni A.¹,McCartney Daniel L.¹,Shi Liu²,Campbell Archie¹,Walker Rosie M.¹³,Ritchie Craig W.⁴,Deary Ian J.⁵,Evans Kathryn L.¹,Nevado‐Holgado Alejo J.²,Hayward Caroline⁶,Porteous David J.¹,McIntosh Andrew M.¹⁷,Lovestone Simon²⁸,Robinson Matthew R.⁹,Marioni Riccardo E.¹

Affiliation:

1. Centre for Genomic and Experimental Medicine Institute of Genetics and Cancer, University of Edinburgh Edinburgh UK

2. Department of Psychiatry University of Oxford Oxford UK

3. Centre for Clinical Brain Sciences, Chancellor's Building, 49 Little France Crescent University of Edinburgh Edinburgh UK

4. Edinburgh Dementia Prevention, Centre for Clinical Brain Sciences University of Edinburgh Edinburgh UK

5. Lothian Birth Cohorts, Department of Psychology University of Edinburgh Edinburgh UK

6. MRC Human Genetics Unit Institute of Genetics and Cancer University of Edinburgh Edinburgh UK

7. Division of Psychiatry, Centre for Clinical Brain Sciences University of Edinburgh Edinburgh UK

8. Neurodegeneration Johnson and Johnson Medical Ltd Wokingham UK

9. Medical Genomics Group Institute of Science and Technology Austria Klosterneuburg Austria

Funder

Scottish Funding Council

Wellcome Trust

Alzheimer's Society

Wellcome

Publisher

Wiley

Subject

Psychiatry and Mental health,Neurology (clinical)

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/dad2.12280

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3. Largest GWAS (N = 1,126,563) of Alzheimer's disease implicates microglia and immune cells;Wightman DP;medRxiv,2020

4. CSF and blood biomarkers for the diagnosis of Alzheimer's disease: a systematic review and meta-analysis

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