Affiliation:
1. State Key Laboratory of Food Nutrition and Safety Tianjin University of Science & Technology Tianjin Peoples Republic of China
2. Key Laboratory of Food Nutrition and Safety, Ministry of Education Tianjin University of Science and Technology Tianjin Peoples Republic of China
3. College of Food Science and Engineering Tianjin University of Science and Technology Tianjin Peoples Republic of China
Abstract
AbstractA new exopolysaccharide component named as PC‐EPS was isolated from Cordyceps cicadae, and its structure was determined. PC‐EPS was identified to be constituted of mannose, glucose, and galactose (28.84:1:19.42), with an average molecular weight of 3.72 × 106 Da, according to the results of monosaccharide composition, Fourier transform infrared, nuclear magnetic resonance, periodate oxidation and Smith degradation, and methylation studies. According to structural characterization, PC‐EPS's connection type was made up of →6) ‐α‐d‐Manp (1→, →2) ‐β‐d‐Manp (1→, →4) ‐α‐d‐Manp (1→, →2) ‐α‐d‐Galf (1→, and →4) ‐α‐d‐Galp (1→. PC‐EPS may significantly increase phagocytosis and RAW264.7 cell proliferation. Additionally, by boosting intracellular lysozyme, cellular acid phosphatase, and cellular superoxide dismutase enzyme concentrations, as well as by promoting the generation of cellular NO, it is the potential to regulate the immunological activity of RAW264.7 cells. Additionally, the effects of PC‐EPS on RAW264.7 cells increased their capacities to create tumor necrosis factor‐α and interleukin 6 cytokines, all of which suggested that PC‐EPS had the potential to improve immunomodulatory activity.
Funder
National Natural Science Foundation of China
Subject
Process Chemistry and Technology,Drug Discovery,Applied Microbiology and Biotechnology,Biomedical Engineering,Molecular Medicine,General Medicine,Bioengineering,Biotechnology
Cited by
1 articles.
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