Photothermal Aza‐Michael Addition of Divergent Amines to Vinyl Sulfones: A Method Towards Transition Metal‐ and Base‐Free Medium

Author:

Duraisamy Tamilselvan1ORCID,Govindan Karthick1ORCID,Thavasianandam Seenivasan Vijay1,Chen Nian‐Qi1,Liao Zi‐Xian2,Lin Wei‐Yu134ORCID

Affiliation:

1. Department of Medicinal and Applied Chemistry Kaohsiung Medical University Kaohsiung 80708 ROC (Taiwan

2. Institute of Medical Science and Technology National Sun Yat-sen University ROC (Taiwan

3. Department of Medical Research Kaohsiung Medical University Hospital Kaohsiung 80708 ROC (Taiwan

4. Drug Development and Value Creation Research Centre Kaohsiung Medical University Kaohsiung 80708 ROC.(Taiwan

Abstract

AbstractA highly efficient and versatile method has been developed for the photothermal aza‐Michael addition, producing β‐amino sulfones with excellent yields. The protocol uses mild and simple conditions under the batch and continuous flow process and is suitable for synthesis, without the need for transition metal catalysts, ligands, strong acids, or bases. This sustainable approach offers a significant breakthrough in organic synthesis with potential applications in medicinal chemistry and materials science.

Funder

National Science and Technology Council

Publisher

Wiley

Subject

Organic Chemistry

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