Metal‐Free Substituent‐Controlled Direct Synthesis of Unprecedented Iminotetrazoles via One‐pot Ugi‐Azide Reaction

Abstract

AbstractEasy operation, readily accessible starting materials, and direct synthesis of iminotetrazoles via metal‐free aerobic oxidation were achieved in one‐pot Ugi‐azide multicomponent reactions. A study of the reactivity of 2‐hydroxybenzaldehyde (Salicylaldehyde) as single reactant replacement (SSR) in classical Ugi reaction has been carried out showing an outcome that differs by simply varying the ortho‐substituents of the benzaldehyde moiety. In doing so, various substituted imino tetrazole products could be obtained directly in one step by simple execution without oxidation step in good yields. Characterization of these new iminotetrazole products was confirmed by X‐ray analysis.