Affiliation:
1. Department of Diagnostic and Biological Sciences School of Dentistry, University of Minnesota Minneapolis Minnesota USA
2. Department of Medicine Division of Infectious Disease, Brigham and Women's Hospital and Harvard Medical School Boston Massachusetts USA
Abstract
AbstractThe human genome is organized in an extremely complexed yet ordered way within the nucleus. Genome organization plays a critical role in the regulation of gene expression. Viruses manipulate the host machinery to influence host genome organization to favor their survival and promote disease development. Epstein‐Barr virus (EBV) is a common human virus, whose infection is associated with various diseases, including infectious mononucleosis, cancer, and autoimmune disorders. This review summarizes our current knowledge of how EBV uses different strategies to control the cellular 3D genome organization to affect cell gene expression to transform normal cells into lymphoblasts.
Funder
National Institute of Allergy and Infectious Diseases
National Institute of Dental and Craniofacial Research
Subject
Infectious Diseases,Virology