New and Emerging Research on Solute Carrier and ATP Binding Cassette Transporters in Drug Discovery and Development: Outlook From the International Transporter Consortium

Author:

Giacomini Kathleen M.1ORCID,Yee Sook W.1ORCID,Koleske Megan L.1,Zou Ling2,Matsson Pär3,Chen Eugene C.4,Kroetz Deanna L.1,Miller Miles A.5,Gozalpour Elnaz6,Chu Xiaoyan7

Affiliation:

1. Department of Bioengineering and Therapeutic Sciences University of California, San Francisco San Francisco California USA

2. Pharmacokinetics and Drug Metabolism Amgen Inc. South San Francisco California USA

3. Department of Pharmacology Sahlgrenska Academy University of Gothenburg Gothenburg Sweden

4. Department of Drug Metabolism and Pharmacokinetics Genentech, Inc. South San Francisco California USA

5. Center for Systems Biology Massachusetts General Hospital Boston Massachusetts USA

6. Drug Safety and Metabolism IMED Biotech Unit Safety and ADME Translational Sciences Department AstraZeneca R&D Cambridge UK

7. Department of ADME and Discovery Toxicology Merck & Co. Inc Kenilworth New Jersey USA

Funder

National Institutes of Health

Publisher

Wiley

Subject

Pharmacology (medical),Pharmacology

Reference150 articles.

1. International Transporter Consortium. Publications n.d. Available from:https://www.itc‐transporter.org/publications.html

2. Influence of Transporter Polymorphisms on Drug Disposition and Response: A Perspective From the International Transporter Consortium

3. Transporters in drug development: 2021 ITC update on emerging transporters of clinical importance.;Bendayan R.;Clin. Pharmacol. Ther.,2022

4. Transcriptional and post‐transcriptional regulation of transporters;Brouwer K.;Clin. Pharmacol. Ther.

5. CRISPR-Cas9: A New Addition to the Drug Metabolism and Disposition Tool Box

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