Discovery of a Highly Selective Glycogen Synthase Kinase‐3 Inhibitor (PF‐04802367) That Modulates Tau Phosphorylation in the Brain: Translation for PET Neuroimaging-Reference-Cited by-同舟云学术

Discovery of a Highly Selective Glycogen Synthase Kinase‐3 Inhibitor (PF‐04802367) That Modulates Tau Phosphorylation in the Brain: Translation for PET Neuroimaging

Published:2016-06-29 Issue:33 Volume:55 Page:9601-9605
ISSN:1433-7851
Container-title:Angewandte Chemie International Edition
language:en
Short-container-title:Angew. Chem. Int. Ed.

Author:

Liang Steven H.¹,Chen Jinshan Michael²,Normandin Marc D.¹,Chang Jeanne S.²,Chang George C.²,Taylor Christine K.²,Trapa Patrick³,Plummer Mark S.²,Para Kimberly S.²,Conn Edward L.²,Lopresti‐Morrow Lori²,Lanyon Lorraine F.²,Cook James M.²,Richter Karl E. G.²,Nolan Charlie E.²,Schachter Joel B.²,Janat Fouad²,Che Ye²,Shanmugasundaram Veerabahu²,Lefker Bruce A.³,Enerson Bradley E.²,Livni Elijahu¹,Wang Lu¹,Guehl Nicolas J.¹,Patnaik Debasis⁴,Wagner Florence F.⁵,Perlis Roy⁵⁴,Holson Edward B.⁵,Haggarty Stephen J.⁴,El Fakhri Georges¹,Kurumbail Ravi G.²,Vasdev Neil¹

Affiliation:

1. Gordon Center for Medical Imaging & Nuclear Medicine and Molecular Imaging Massachusetts General Hospital & Department of Radiology Harvard Medical School Boston MA 02114 USA

2. Pfizer Worldwide Research and Development, Groton Laboratories Eastern Point Road Groton CT 06340 USA

3. Pfizer Worldwide Research and Development 610 Main Street Cambridge MA 02139 USA

4. Departments of Neurology & Psychiatry Massachusetts General Hospital Harvard Medical School 185 Cambridge Street Boston MA 02114 USA

5. Stanley Center for Psychiatric Research Broad Institute 415 Main Street Cambridge MA o2142 USA

Funder

U.S. Department of Energy

National Institutes of Health

Publisher

Wiley

Subject

General Chemistry,Catalysis

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/anie.201603797

Reference39 articles.

2. Molecular cloning and expression of glycogen synthase kinase-3/factor A.

3. The glamour and gloom of glycogen synthase kinase-3

4. Pharmacological inhibitors of glycogen synthase kinase 3

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