Affiliation:
1. School of Public Health Nantong University Nantong Jiangsu 226019 P.R. China
2. Department of Laboratory Medicine Wuxi No. 5 People's Hospital Affiliated Jiangnan University Wuxi Jiangsu 214005 P.R. China
3. Department of Radiotherapy Nantong Tumor Hospital Tumor Hospital Affiliated to Nantong University Nantong Jiangsu 226361 P.R. China
4. College of Engineering and Applied Sciences Nanjing University Nanjing Jiangsu 210023 P.R. China
Abstract
AbstractChemotherapy drugs continue to be the main component of oncology treatment research and have been proven to be the main treatment modality in tumor therapy. However, the poor delivery efficiency of cancer therapeutic drugs and their potential off‐target toxicity significantly limit their effectiveness and extensive application. The recent integration of biological carriers and functional agents is expected to camouflage synthetic biomimetic nanoparticles for targeted delivery. The promising candidates, including but not limited to red blood cells and their membranes, platelets, tumor cell membrane, bacteria, immune cell membrane, and hybrid membrane are typical representatives of biological carriers because of their excellent biocompatibility and biodegradability. Biological carriers are widely used to deliver chemotherapy drugs to improve the effectiveness of drug delivery and therapeutic efficacy in vivo, and tremendous progress is made in this field. This review summarizes recent developments in biological vectors as targeted drug delivery systems based on microenvironmental stimuli‐responsive release, thus highlighting the potential applications of target drug biological carriers. The review also discusses the possibility of clinical translation, as well as the exploitation trend of these target drug biological carriers.
Funder
Natural Science Foundation of Nantong City
Science and Technology Project of Nantong City
National Natural Science Foundation of China
Subject
Materials Chemistry,Polymers and Plastics,Biomaterials,Bioengineering,Biotechnology