Affiliation:
1. Department of Enterprise Engineering University of Rome “Tor Vergata” Via del Politecnico 1 Rome 00133 Italy
2. IRCCS Fondazione Santa Lucia Rome 00179 Italy
3. Multispecialty Department of Oral Surgery – Periodontology and Implant‐Prosthodontic Rehabilitation Università Cattolica del Sacro Cuore Largo F. Vito 1 Rome 00168 Italy
4. Department of Life Science and Public Health Università Cattolica del Sacro Cuore Largo F. Vito, 1 Rome 00168 Italy
5. Department of Biology University of Rome “Tor Vergata” Via della Ricerca scientifica 1 Rome 00133 Italy
Abstract
AbstractThis study aims to obtain a cyto‐compatible 3D printable bio‐resin for the manufacturing of meshes designed from acquired real patients’ bone defect to be used in future for guided bone regeneration (GBR), achieving the goal of personalized medicine, decreasing surgical, recovery time, and patient discomfort. To this purpose, a biobased, biocompatible, and photo‐curable resin made of acrylated epoxidized soybean oil (AESO) diluted with soybean oil (SO) is developed and 3D printed using a commercial digital light processing (DLP) 3D printer. 3D printed samples show good thermal properties, allowing for thermally‐based sterilization process and mechanical properties typical of crosslinked natural oils (i.e., E = 12 MPa, UTS = 1.5 MPa), suitable for the GBR application in the oral surgery. The AESO‐SO bio‐resin proves to be cytocompatible, allowing for fibroblast cells proliferation (viability at 72 h > 97%), without inducing severe inflammatory response when co‐cultured with macrophages, as demonstrated by cytokine antibody arrays, that is anyway resolved in the first 24 h. Moreover, accelerated degradation tests prove that the bio‐resin is biodegradable in hydrolytic environments.
Subject
Materials Chemistry,Polymers and Plastics,Biomaterials,Bioengineering,Biotechnology