“Smart” Stimuli‐responsive Injectable Gels for Bone Tissue Engineering Application

Author:

Li Hanke1,Hao Zhuowen1,Zhang Shuwei1,Li Beihai1,Wang Yi1,Wu Xinxin1,Hu Yingkun1,Chen Renxin1,Chen Tianhong1,Li Jingfeng1ORCID

Affiliation:

1. Department of Orthopedics Zhongnan Hospital of Wuhan University Donghu Road 169 430071 China

Abstract

AbstractBone grafting, as the current gold‐standard for large scaled bone damage of various causes, has faced challenges from both the source and appliance. Emerging new tissue engineering substitutes are demonstrating more options and possibilities, with their improved biocompatibility, accessibility, and customizable function. Amongst them, injectable gels (IGs) are a class of gel material displaying astonishing non‐invasive properties and surgical viability. While possessing responsiveness toward specific stimuli, they change their physical form in vivo, thus serving as wonderful biomaterials and drug delivery systems. In this review, the mechanics of stimuli‐responsive IGs developed during the past decade are illustrated. Two branches of crosslinked gels – co‐valent and non‐covalent crosslinked IGs and their composition and customization are introduced. In conclusion, the present trend in bone tissue engineering research is summarized and made an outlook for future. It is hoped that this comprehensive review can provide a proper reference for the development of new IGs.

Funder

National Natural Science Foundation of China

Publisher

Wiley

Subject

Materials Chemistry,Polymers and Plastics,Biomaterials,Bioengineering,Biotechnology

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