A Periosteum‐Bioinspired Electrospun Janus Membrane with Antibacterial and Osteogenic Dual‐Function

Abstract

AbstractFor a guided bone regeneration membrane, it is critical to possess osteogenic capability while inhibiting infection caused by bacteria. Inspired by the bilayer structure of the native periosteum, an electrospun Janus membrane with osteogenic and antibacterial dual‐function was fabricated for guided bone regeneration. Hydrophilic moxifloxacin (MXF) and hydrophobic icariin (ICA) were loaded in the nanofibers made of a mixture of polycaprolactone (PCL) and gelatin at the top and bottom layers respectively, leading to the opposing hydrophilic/hydrophobic properties of the bilayer Janus membranes. The as‐obtained Janus membrane exhibited excellent physical properties (tensile strength > 6.0 MPa) and robust biocompatibility, indicating the immense potential as a suitable replacement for the native periosteum. The membrane had a superior surface morphology and outstanding degradation performance in vitro. Besides, the rapid release of MXF and the slow release of ICA could meet the different needs of drug release rates. Only ∼30% ICA was released from the as‐obtained Janus membrane after 21 days while almost 80% release of MXF was released. Mimicking the bilayer structure of the native periosteum, the electrospun Janus membrane containing ICA and MXF exhibited excellent comprehensive properties, which provides a promising strategy for preparing multi‐functional scaffolds for tissue engineering.This article is protected by copyright. All rights reserved