Fluorous Tagged Peptides for Intracellular Delivery and Biomedical Imaging

Author:

Ding Lei1,Rong Guangyu2ORCID,Cheng Yiyun234ORCID

Affiliation:

1. Department of Ultrasound Medicine Second Affiliated Hospital of Anhui Medical University Hefei 230601 P. R. China

2. South China Advanced Institute for Soft Matter Science and Technology School of Emergent Soft Matter South China University of Technology Guangzhou 510640 P. R. China

3. Shanghai Key Laboratory of Regulatory Biology School of Life Sciences East China Normal University Shanghai 200241 P. R. China

4. Fengxian District Central Hospital‐ECNU Joint Center of Translational Medicine Fengxian District Central Hospital Shanghai 200241 P. R. China

Abstract

AbstractFluorous tagged peptides have shown promising features for biomedical applications such as drug delivery and multimodal imaging. The bioconjugation of fluoroalkyl ligands onto cargo peptides greatly enhances their proteolytic stability and membrane penetration via a proposed “fluorine effect”. The tagged peptides also efficiently deliver other biomolecules such as DNA and siRNA into cells via a co‐assembly strategy. The fluoroalkyl chains on peptides with antifouling properties enable efficient gene delivery in the presence of serum proteins. Besides intracellular biomolecule delivery, the amphiphilic peptides can be used to stabilized perfluorocarbon‐filled microbubbles for ultrasound imaging. The fluorine nucleus on fluoroalkyls provides intrinsic probes for background‐free magnetic resonance imaging. Labeling of fluorous tags with radionuclide 18F also allows tracing the biodistribution of peptides via positron emission tomography imaging. This mini‐review will discuss properties and mechanism of the fluorous tagged peptides in these applications.

Funder

National Natural Science Foundation of China

Publisher

Wiley

Subject

Materials Chemistry,Polymers and Plastics,Biomaterials,Bioengineering,Biotechnology

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