Affiliation:
1. School of Materials Science and Engineering Tianjin Key Laboratory of Composite and Functional Materials Tianjin University Tianjin 300350 China
Abstract
AbstractThe imbalance of extrinsic and intrinsic healing of tendon is thought to be the main cause of peritendinous adhesions. In this work, an injectable supramolecular poly(N‐(2‐hydroxypropyl) acrylamide) (PHPAm) hydrogel is prepared merely via side chain hydrogen‐bonding crosslinks. This PHPAm exhibits good antifouling and self‐healing properties. The supramolecular hydrogel simultaneously loaded with Prussian blue (PB) nanoparticles and platelet lysate (PL) is explored as a functional physical barrier, which can significantly resist the adhesion of fibrin and fibroblasts, attenuate the local inflammatory response, and enhance the tenocytes activity, thus balancing extrinsic and intrinsic healing. The PHPAm hydrogel is shown to prevent peritendinous adhesions considerably by inhibiting NF‐κB inflammatory pathway and TGF‐β1/Smad3‐mediated fibrosis pathway, thereby significantly improving tendon repair by releasing bioactive factors to regulate the tenocytes behavior. This work provides a new strategy for developing physical barriers to prevent peritendinous adhesions and promote tissue repair effectively.
Funder
State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources
National Natural Science Foundation of China
Subject
Materials Chemistry,Polymers and Plastics,Biomaterials,Bioengineering,Biotechnology