Affiliation:
1. School of Chemical Engineering and Technology Tianjin University Tianjin 300350 China
2. NHC Key Laboratory of Hormones and Development Tianjin Key Laboratory of Metabolic Diseases Chu Hsien‐I Memorial Hospital and Tianjin Institute of Endocrinology Tianjin Medical University Tianjin 300134 China
Abstract
AbstractIn order to achieve long‐term and controllable release of anti‐tumor drugs at specific sites, temperature/pH responsive nanoparticles encapsulating 5‐fluorouracil and methotrexate in situ are prepared through dispersion photopolymerization under green LED irradiation. The physicochemical properties of nanoparticles are characterized by scanning electron microscopy, Fourier transform infrared, dynamic light scattering, thermogravimetric/differential scanning calorimetry, and X‐ray diffraction. In vitro drug release at different temperatures and pH values is examined to ascertain the release pattern of two drugs, which can be well described by Korsmeyer–Peppas kinetic model. The cytotoxicity evaluation illustrates that the tumor cells could be more effectively killed by the drug‐loaded nanoparticles, and the improved therapeutic effect is attributed to the controllable and sustainable drug release as well as the enhanced cellular uptake. The blood safety and good biocompatibility of nanoparticles are further confirmed by hemolysis assay, indicating the prepared nanoparticles are potential candidates for effective tumor treatment.
Funder
National Natural Science Foundation of China