Hydrogels for the Treatment of Myocardial Infarction: Design and Therapeutic Strategies

Author:

Liang Jiaheng12,Lv Ronghao1,Li Maorui1,Chai Jin1,Wang Shuo1,Yan Wenjun3,Zheng Zijian2,Li Peng1ORCID

Affiliation:

1. Frontiers Science Center for Flexible Electronics (FSCFE) Institute of Flexible Electronics (IFE) Institute of Biomedical Materials and Engineering (IBME) Northwestern Polytechnical University (NPU) Xi'an 710072 China

2. Laboratory for Advanced Interfacial Materials and Devices Department of Applied Biology and Chemical Technology (ABCT) Research Institute for Intelligent Wearable Systems (RI‐IWEAR) The Hong Kong Polytechnic University Hong Kong SAR 999077 China

3. Department of Cardiology Xijing Hospital Fourth Military Medical University Xi'an 710072 China

Abstract

AbstractCardiovascular diseases (CVDs) have become the leading global burden of diseases in recent years and are the primary cause of human mortality and loss of healthy life expectancy. Myocardial infarction (MI) is the top cause of CVDs‐related deaths, and its incidence is increasing worldwide every year. Recently, hydrogels have garnered great interest from researchers as a promising therapeutic option for cardiac tissue repair after MI. This is due to their excellent properties, including biocompatibility, mechanical properties, injectable properties, anti‐inflammatory properties, antioxidant properties, angiogenic properties, and conductive properties. This review discusses the advantages of hydrogels as a novel treatment for cardiac tissue repair after MI. The design strategies of various hydrogels in MI treatment are then summarized, and the latest research progress in the field is classified. Finally, the future perspectives of this booming field are also discussed at the end of this review.

Funder

Fundamental Research Funds for the Central Universities

National Natural Science Foundation of China

Publisher

Wiley

Subject

Materials Chemistry,Polymers and Plastics,Biomaterials,Bioengineering,Biotechnology

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