1. Department of Internal Medicine; E-Da Hospital/I-Shou University; Kaohsiung Taiwan
2. Institute of Preventive Medicine College of Public Health; National Taiwan University; Taipei Taiwan
3. Department of Internal Medicine; National Taiwan University Hospital; Taipei Taiwan
4. Department of Medicine College of Medicine; National Taiwan University; Taipei Taiwan
5. Department of Internal Medicine; National Taiwan University Hospital Yun-Lin Branch; Dou-Liou City Yun-Lin County Taiwan