Mendelian Randomization Analysis Reveals a Causal Influence of Circulating Sclerostin Levels on Bone Mineral Density and Fractures

Author:

Zheng Jie1,Maerz Winfried234,Gergei Ingrid4,Kleber Marcus4,Drechsler Christiane5,Wanner Christoph5,Brandenburg Vincent5,Reppe Sjur67,Gautvik Kaare M78,Medina‐Gomez Carolina9,Shevroja Enisa9,Gilly Arthur1011,Park Young‐Chan1012,Dedoussis George13,Zeggini Eleftheria1011,Lorentzon Mattias141516ORCID,Henning Petra14,Lerner Ulf H14,Nilsson Karin H14,Movérare‐Skrtic Sofia14,Baird Denis1,Elsworth Benjamin1,Falk Louise1,Groom Alix117,Capellini Terence D1819,Grundberg Elin2021,Nethander Maria14,Ohlsson Claes14,Davey Smith George1,Tobias Jonathan H122

Affiliation:

1. MRC Integrative Epidemiology Unit (IEU), Bristol Medical School, University of BristolBristol UK

2. Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of GrazGraz Austria

3. SYNLAB Academy, SYNLAB Holding Deutschland GmbHMannheim Germany

4. Vth Department of Medicine (Nephrology, Hypertensiology, Rheumatology, Endocrinology, Diabetology), Medical Faculty Mannheim, University of HeidelbergMannheim Germany

5. Department of Cardiology and Nephrology, Rhein‐Maas‐Klinikum Würselen Germany

6. Department of Medical Biochemistry, Oslo University HospitalOslo Norway

7. Unger‐Vetlesen Institute, Lovisenberg Diaconal HospitalOslo Norway

8. Institute of Basic Medical Sciences, University of OsloOslo Norway

9. Department of Internal Medicine, Erasmus MC University Medical CenterRotterdam The Netherlands

10. Human Genetics, Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton UK

11. Institute of Translational Genomics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg Germany

12. University of CambridgeCambridge UK

13. Department of Nutrition and Dietetics, School of Health Science and Education, Harokopio UniversityAthens Greece

14. Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, University of GothenburgGothenburg Sweden

15. Geriatric Medicine, Institute of Medicine, University of GothenburgGothenburg Sweden

16. Geriatric Medicine Clinic, Sahlgrenska University Hospital, Mölndal Sweden

17. Bristol Bioresource Laboratories, Population Health Sciences, Bristol Medical School, University of BristolBristol UK

18. Human Evolutionary Biology, Harvard UniversityBoston MA USA

19. Broad Institute of MIT and HarvardBoston MA USA

20. Department of Human Genetics, McGill UniversityQuebec Canada

21. Center for Pediatric Genomic Medicine, Children's MercyKansas City MO USA

22. Musculoskeletal Research Unit, University of BristolBristol UK

Funder

Wellcome Trust

Publisher

Wiley

Subject

Orthopedics and Sports Medicine,Endocrinology, Diabetes and Metabolism

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