Application of adhesives in the treatment of cartilage repair

Author:

Feng Haoyang1ORCID,Ang Kai1,Guan Pengfei1,Li Junji1,Meng Huan2,Yang Jian3,Fan Lei4,Sun Yongjian1

Affiliation:

1. Department of Pediatric Orthopedics The Third Affiliated Hospital of Southern Medical University Guangzhou China

2. Postdoc Cartilage Biology AO Research Institute Davos Davos Platz Wellington Switzerland

3. Biomedical Engineering Program School of Engineering Westlake University Hangzhou China

4. Department of Orthopedic Surgery Nanfang Hospital Southern Medical University Guangzhou China

Abstract

AbstractFrom degeneration causing intervertebral disc issues to trauma‐induced meniscus tears, diverse factors can injure the different types of cartilage. This review highlights adhesives as a promising and rapidly implemented repair strategy. Compared to traditional techniques such as sutures and wires, adhesives offer several advantages. Importantly, they seamlessly connect with the injured tissue, deliver bioactive substances directly to the repair site, and potentially alleviate secondary problems like inflammation or degeneration. This review delves into the cutting‐edge advancements in adhesive technology, specifically focusing on their effectiveness in cartilage injury treatment and their underlying mechanisms. We begin by exploring the material characteristics of adhesives used in cartilage tissue, focusing on essential aspects like adhesion, biocompatibility, and degradability. Subsequently, we investigate the various types of adhesives currently employed in this context. Our discussion then moves to the unique role adhesives play in addressing different cartilage injuries. Finally, we acknowledge the challenges currently faced by this promising technology.

Funder

Natural Science Foundation of Guangdong Province

Publisher

Wiley

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