A meta‐analysis of deep brain structural shape and asymmetry abnormalities in 2,833 individuals with schizophrenia compared with 3,929 healthy volunteers via the ENIGMA Consortium

Author:

Gutman Boris A.12,Erp Theo G.M.34,Alpert Kathryn5,Ching Christopher R. K.6ORCID,Isaev Dmitry7,Ragothaman Anjani8,Jahanshad Neda6,Saremi Arvin6,Zavaliangos‐Petropulu Artemis6,Glahn David C.9ORCID,Shen Li10ORCID,Cong Shan10ORCID,Alnæs Dag11,Andreassen Ole Andreas11,Doan Nhat Trung11,Westlye Lars T.1112ORCID,Kochunov Peter13,Satterthwaite Theodore D.14ORCID,Wolf Daniel H.14,Huang Alexander J.3,Kessler Charles3,Weideman Andrea3,Nguyen Dana15,Mueller Bryon A.16,Faziola Lawrence17,Potkin Steven G.17,Preda Adrian17,Mathalon Daniel H.1819,Bustillo Juan20,Calhoun Vince2122,Ford Judith M.1923,Walton Esther24,Ehrlich Stefan25,Ducci Giuseppe26,Banaj Nerisa27,Piras Fabrizio27ORCID,Piras Federica27,Spalletta Gianfranco2728ORCID,Canales‐Rodríguez Erick J.29,Fuentes‐Claramonte Paola29,Pomarol‐Clotet Edith29,Radua Joaquim2930,Salvador Raymond29ORCID,Sarró Salvador29,Dickie Erin W.31,Voineskos Aristotle31,Tordesillas‐Gutiérrez Diana32,Crespo‐Facorro Benedicto33,Setién‐Suero Esther34,Son Jacqueline Mayoral33,Borgwardt Stefan3536,Schönborn‐Harrisberger Fabienne35,Morris Derek37,Donohoe Gary38,Holleran Laurena38,Cannon Dara39,McDonald Colm39,Corvin Aiden4041,Gill Michael4041,Filho Geraldo Busatto42,Rosa Pedro G. P.42,Serpa Mauricio H.42,Zanetti Marcus V.4243,Lebedeva Irina44,Kaleda Vasily45,Tomyshev Alexander44,Crow Tim46,James Anthony46,Cervenka Simon47,Sellgren Carl M48,Fatouros‐Bergman Helena47,Agartz Ingrid11,Howells Fleur4950,Stein Dan J.495051,Temmingh Henk49,Uhlmann Anne4952,Zubicaray Greig I.53,McMahon Katie L.54,Wright Margie55,Cobia Derin556,Csernansky John G.5,Thompson Paul M.6,Turner Jessica A.57,Wang Lei558ORCID

Affiliation:

1. Department of Biomedical Engineering Illinois Institute of Technology Chicago Illinois USA

2. Institute for Information Transmission Problems (Kharkevich Institute) Moscow Russia

3. Clinical Translational Neuroscience Laboratory, Department of Psychiatry and Human Behavior University of California Irvine Irvine California USA

4. Center for the Neurobiology of Learning and Memory University of California Irvine Irvine California USA

5. Department of Psychiatry and Behavioral Sciences Northwestern University Feinberg School of Medicine Chicago Illinois USA

6. Imaging Genetics Center, Mark & Mary Stevens Neuroimaging & Informatics Institute, Keck School of Medicine University of Southern California Los Angeles California USA

7. Department of Biomedical Engineering Duke University Durham North Carolina USA

8. Department of biomedical engineering Oregon Health and Science university Portland Oregon USA

9. Department of Psychiatry Boston Children's Hospital and Harvard Medical School Boston Massachusetts USA

10. Department of Biostatistics, Epidemiology and Informatics University of Pennsylvania Philadelphia Pennsylvania USA

11. NORMENT, Division of Mental Health and Addiction Oslo University Hospital & Institute of Clinical Medicine, University of Oslo Oslo Norway

12. Department of Psychology University of Oslo Oslo Norway

13. Department of Psychiatry University of Maryland School of Medicine Baltimore Maryland USA

14. Department of Psychiatry University of Pennsylvania Perelman School of Medicine Philadelphia Pennsylvania USA

15. Department of Pediatrics University of California Irvine Irvine California USA

16. Department of Psychiatry and Behavioral Sciences University of Minnesota Minneapolis Minnesota USA

17. Department of Psychiatry and Human Behavior University of California Irvine Irvine California USA

18. Department of Psychiatry and Weill Institute for Neurosciences University of California San Francisco San Francisco California USA

19. Judith Ford Mental Health VA San Francisco Healthcare System San Francisco California USA

20. Departments of Psychiatry & Neuroscience University of New Mexico Albuquerque New Mexico USA

21. Tri‐institutional Center for Translational Research in Neuroimaging and Data Science (TReNDS) [Georgia State University, Georgia Institute of Technology] Emory University Atlanta Georgia USA

22. Department of Electrical and Computer Engineering The University of New Mexico Albuquerque New Mexico USA

23. Department of Psychiatry and Behavioral Sciences University of California San Francisco California USA

24. Department of Psychology University of Bath Bath UK

25. Division of Psychological & Social Medicine and Developmental Neurosciences Faculty of Medicine, TU‐Dresden Dresden Germany

26. Mental Health Department ASL Roma1 DSM Rome Italy

27. Laboratory of Neuropsychiatry IRCCS Santa Lucia Foundation Rome Italy

28. Menninger Department of Psychiatry and Behavioral Sciences Baylor College of Medicine Houston Texas USA

29. FIDMAG Germanes Hospitalàries Research Foundation CIBERSAM Barcelona Spain

30. Institut d'Investigacions Biomdiques August Pi i Sunyer (IDIBAPS) Barcelona Spain

31. Centre for Addiction and Mental Health (CAMH) Toronto Canada

32. Department of Radiology, IDIVAL Marqués de Valdecilla University Hospital Santander Spain

33. University Hospital Virgen del Rocio, IBiS University of Sevilla, CIBERSAM Sevilla Spain

34. University Hospital Marqués de Valdecilla IDIVAL, CIBERSAM Santander Spain

35. Department of Psychiatry University of Basel Basel Switzerland

36. Department of Psychiatry and Psychotherapy University of Lübeck Lübeck Germany

37. Centre for Neuroimaging and Cognitive Genomics, Discipline of Biochemistry National University of Ireland Galway Galway Ireland

38. Centre for Neuroimaging and Cognitive Genomics, School of Psychology National University of Ireland Galway Galway Ireland

39. Clinical Neuroimaging Laboratory, Centre for Neuroimaging and Cognitive Genomics National University of Ireland Galway Galway Ireland

40. Neuropsychiatric Genetics Research Group, Department of Psychiatry Trinity College Dublin Dublin Ireland

41. Trinity College Institute of Neuroscience Trinity College Dublin Dublin Ireland

42. Laboratory of Psychiatric Neuroimaging (LIM‐21), Departamento e Instituto de Psiquiatria Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo Sao Paulo SP Brazil

43. Hospital Sirio‐Libanes Sao Paulo SP Brazil

44. Laboratory of Neuroimaging and Multimodal Analysis Mental Health Research Center Moscow Russia

45. Department of Endogenous Mental Disorders Mental Health Research Center Moscow Russia

46. Department of Psychiatry University of Oxford Oxford UK

47. Centre for Psychiatry Reserach, Department of Clinical Neuroscience Karolinska Institutet, & Stockholm Health Care Services, Region Stockholm Stockholm Sweden

48. Department of Physiology and Pharmacology Karolinska Institutet Stockholm Sweden

49. Department of Psychiatry and Mental Health, Faculty of Health Sciences University of Cape Town Cape Town WC South Africa

50. Neuroscience Institute University of Cape Town, Cape Town WC South Africa

51. SA MRC Unit on Risk & Resilience in Mental Disorders University of Cape Town Cape Town WC South Africa

52. Department of Child and Adolescent Psychiatry TU Dresden Germany

53. School of Psychology, Faculty of Health Queensland University of Technology (QUT) Brisbane QLD Australia

54. School of Clinical Sciences Queensland University of Technology (QUT) Brisbane QLD Australia

55. Queensland Brain Institute University of Queensland Brisbane QLD Australia

56. Department of Psychology and Neuroscience Center Brigham Young University Provo Utah USA

57. Psychology & Neuroscience Georgia State University Atlanta Georgia USA

58. Department of Psychiatry and Behavioral Health Ohio State University Wexner Medical Center Columbus Ohio USA

Funder

Center for Integrated Healthcare, U.S. Department of Veterans Affairs

Commonwealth Health Research Board

Conselho Nacional de Desenvolvimento Científico e Tecnológico

Department of Energy, Labor and Economic Growth

Forskningsrådet om Hälsa, Arbetsliv och Välfärd

Fundação Amazônia Paraense de Amparo à Pesquisa

Instituto de Salud Carlos III

National Health and Medical Research Council

National Institutes of Health

National Science Foundation

Norges Forskningsråd

Science Foundation Ireland

Wellcome Trust

Publisher

Wiley

Subject

Neurology (clinical),Neurology,Radiology, Nuclear Medicine and imaging,Radiological and Ultrasound Technology,Anatomy

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