Long‐term outcomes of patients with oral cavity cancer receiving postoperative radiotherapy after salvage neck dissection for cervical lymph node recurrence-Reference-Cited by-全球学者库

Long‐term outcomes of patients with oral cavity cancer receiving postoperative radiotherapy after salvage neck dissection for cervical lymph node recurrence

Published:2023-12-18 Issue: Volume: Page:
ISSN:1043-3074
Container-title:Head & Neck
language:en
Short-container-title:Head & Neck

Author:

Fujisawa Takeshi¹²³^ORCID,Motegi Atsushi¹³^ORCID,Hirata Hidenari¹³^ORCID,Zenda Sadamoto¹³,Hojo Hidehiro¹³,Nakamura Masaki¹³,Oyoshi Hidekazu¹,Tomizawa Kento¹^ORCID,Zhou Yuzheng¹,Fukushi Keiko¹,Kageyama Shun‐Ichiro¹³,Enokida Tomohiro⁴,Okano Susumu⁴,Tahara Makoto⁴,Shinozaki Takeshi⁵,Hayashi Ryuichi⁵,Matsuura Kazuto⁵,Akimoto Tetsuo¹³

Affiliation:

1. Department of Radiation Oncology National Cancer Center Hospital East Kashiwa Japan

2. Course of Advanced Clinical Research of Cancer Juntendo University Graduate School of Medicine Tokyo Japan

3. Division of Radiation Oncology and Particle Therapy Exploratory Oncology Research and Clinical Trial Center, National Cancer Center Kashiwa Japan

4. Department of Head and Neck Medical Oncology National Cancer Center Hospital East Kashiwa Japan

5. Department of Head and Neck Surgery National Cancer Center Hospital East Kashiwa Japan

Abstract

AbstractBackgroundsWe aimed to clarify the outcomes of postoperative radiotherapy (PORT) after salvage neck dissection for cervical lymph node (LN) recurrence in oral cavity cancer.MethodsWe retrospectively evaluated overall survival (OS), recurrence‐free survival (RFS), recurrence patterns, and adverse events of 51 patients with high‐risk features receiving PORT after salvage neck dissection between 2009 and 2019.ResultsAfter a median follow‐up of 7.4 years from PORT initiation, the 7‐year OS and RFS rates were 66.3% (95% CI: 54.0–81.3) and 54.6% (95% CI: 42.1–70.9), respectively. Age <70 years and isolated LN recurrence were significantly associated with longer OS and RFS. Among the 22 patients who experienced recurrence, 14 experienced recurrence within the radiation field. PORT‐related grade 3 acute mucositis (35%) and late adverse events (osteoradionecrosis [4%] and laryngeal stenosis [2%]) were observed.ConclusionsPORT after salvage neck dissection for cervical LN recurrence achieved good survival with acceptable toxicity.

Funder

Japan Agency for Medical Research and Development

Publisher

Wiley

Subject

Otorhinolaryngology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/hed.27609

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