Mutational landscape of head and neck cancer and cervical cancer in Chinese and Western population

Abstract

AbstractBackgroundWe aimed to unbiasedly map the genetic mutation profile of HNSC and CESC associated with HPV status in the Chinese population (SYSU‐cohort) and compare them with Western population (TCGA‐cohort).MethodsFifty‐one HNSC patients (SYSU‐HNSC) and 38 CESC patients (SYSU‐CESC) were enrolled in this study. Genomic alterations were examined, and the profile was produced using the YuanSuTM450 gene panel (OrigiMed, Shanghai, China). The altered genes were inferred and compared to Western patients from TCGA cohorts.ResultsCompared to the TCGA‐HNSC cohort, FGFR3 mutation was identified as a novel target in SYSU‐HNSC with therapeutic potential. Compared to the TCGA‐CESC cohort, some epigenetic regulation‐associated genes were frequently mutated in SYSU‐CESC cohort (KMT2C, KMT2D, KDM5C, KMT2A).ConclusionIn summary, our study provides unbiased insights into the genetic landscape of HNSC and CESC in the Chinese population and highlights potential novel therapeutic targets that may benefit Chinese patients.