Biomimetic and Biological Applications of DNA Coacervates

Abstract

Comprehensive SummaryRecent progress in nanotechnology and synthetic biology has demonstrated the potential of DNA coacervates for biomimetic and biological applications. DNA coacervates are micron‐scale, membrane‐free, spherical structures formed by liquid‐liquid phase separation of DNA materials. They uniquely combine the programmability of DNA with the fluidic properties of coacervates, allowing for controlled modulation of their structures, biomimetic and biological functions, and dynamic behaviors through rational sequence design. This review summarizes methods for the formation of different DNA coacervates and explores their extensive applications in biomimicry, biosensing and therapeutics. Limitations and prospects of DNA coacervates are also discussed. Key Scientists