Affiliation:
1. Department of Chemistry Fudan University 2005 Songhu Road Shanghai 200438 China
2. Zhuhai Fudan Innovation Institute Zhuhai Guangdong 519000 China
3. Fudan Zhangjiang Institute Shanghai 201203 China
4. School of Chemistry and Chemical Engineering Henan Normal University Xinxiang Henan 453007 China
Abstract
Comprehensive SummaryA highly enantioselective palladium‐catalyzed intramolecular Heck reaction of unactivated alkenes is developed, which provides a powerful route to access a broad range of chiral 3,3‐disubstituted‐2,3‐dihydrobenzofurans bearing all‐carbon quaternary stereocenter of interest in pharmaceutical research. Its salient features include high yield, excellent chemo‐ and enantioselectivity, mild conditions, a broad substrate scope as well as versatile transformations of the product.
Funder
National Natural Science Foundation of China
China Postdoctoral Science Foundation
Science and Technology Commission of Shanghai Municipality
Shanghai Municipal Education Commission
National Key Research and Development Program of China