Characterization of human CD4+EOMES+GzmK+ T‐cell subsets unveils an uncoupling of suppressive functions from IL‐10‐producing capacities-Reference-Cited by-同舟云学术

Characterization of human CD4⁺EOMES⁺GzmK⁺ T‐cell subsets unveils an uncoupling of suppressive functions from IL‐10‐producing capacities

Published:2024-02-23 Issue:4 Volume:54 Page:
ISSN:0014-2980
Container-title:European Journal of Immunology
language:en
Short-container-title:Eur J Immunol

Author:

Pulvirenti Nadia¹,Silvetri Ylenia¹,Clemente Francesca¹^ORCID,Bosotti Roberto¹,Carelli Elena¹,Moschetti Giorgia¹²^ORCID,Gruarin Paola¹,Vasco Chiara¹,Crosti Maria Cristina¹,Sarnicola Maria Lucia¹,Valenti Luca³⁴⁵,Prati Daniele³,Abrignani Sergio¹⁶,Geginat Jens¹⁶^ORCID

Affiliation:

1. INGM Istituto Nazionale di Genetica Molecolare ‘Romeo ed Enrica Invernizzi’ Milan Italy

2. Department of Pharmaceutical Sciences (DISFARM) Università degli Studi Milan Italy

3. Department of Transfusion Medicine Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico Milan Italy

4. Biological Resource Center Unit Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico Milan Italy

5. Department of Pathophysiology and Transplantation Università degli Studi Milan Italy

6. Department of Clinical Sciences and Community Health Università degli Studi Milan Italy

Funder

Fondazione Italiana Sclerosi Multipla

Associazione Italiana per la Ricerca sul Cancro

Fondazione Telethon

Publisher

Wiley

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/eji.202350675

Reference16 articles.

1. Role of regulatory T cells and FOXP3 in human diseases

2. Eomesodermin‐expressing type 1 regulatory (EOMES⁺Tr1)‐like T cells: Basic biology and role in immune‐mediated diseases

3. IL-10 promotes homeostatic proliferation of human CD8+memory T cells and, when produced by CD1c+DCs, shapes naive CD8+T-cell priming

4. Eomesodermin controls a unique differentiation program in human IL‐10 and IFN‐γ coproducing regulatory T cells

5. Eomes is sufficient to regulate IL-10 expression and cytotoxic effector molecules in murine CD4+ T cells

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