A validated HPLC‐MS/MS method for determination of simmitecan and its metabolite chimmitecan in human plasma and its application to a pharmacokinetic study in Chinese patients with advanced solid tumor

Author:

Zhou Jun1,Zhan Yan2,Zhong Dafang2,Chen Xiaoyan2,Zhang Yifan2,Zhang Qi1,Bo Yunhai3,Shen Lin1,Gong Jifang1,Li Jian1,Yang Fen3ORCID

Affiliation:

1. Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing) Department of Gastrointestinal Oncology Peking University Cancer Hospital & Institute Beijing P. R. China

2. State Key Laboratory of Drug Research Shanghai Institute of Materia Medica Chinese Academy of Sciences Shanghai P. R. China

3. Key laboratory of Carcinogenesis and Translational Research (Ministry of Education) National Drug Clinical Trial Center Peking University Cancer Hospital & Institute Beijing P. R. China

Funder

National Natural Science Foundation of China

Publisher

Wiley

Subject

Filtration and Separation,Analytical Chemistry

Reference17 articles.

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2. Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase I.

3. Identification of mammalian DNA topoisomerase I as an intracellular target of the anticancer drug camptothecin;Hsiang YH;Cancer Res,1988

4. Topoisomerase I inhibitors: camptothecins and beyond

5. Use of camptothecin‐resistant mammalian cell lines to evaluate the role of topoisomerase I in the antiproliferative activity of the indolocarbazole, NB‐506, and its topoisomerase I binding site;Urasaki Y;Cancer Res,2001

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