White analytical chemistry‐driven stability‐indicating concomitant chromatographic estimation of thiocolchicoside and aceclofenac using response surface analysis and red, green, and blue model

Author:

Prajapati Pintu1ORCID,Pulusu Veera Shakar2,Shah Shailesh1

Affiliation:

1. Department of Quality Assurance Maliba Campus Maliba Pharmacy College, Tarsadi, Mahuva Surat India

2. Department of Chemistry and Biochemistry Ohio University Athens Ohio USA

Abstract

White analytical chemistry is a novel concept for the assessment of analytical methods on basis of its validation efficiency, greenness power, and economical efficiency. White analytical chemistry‐driven stability indicating chromatographic method has been developed for the concomitant analysis of thiocolchicoside and aceclofenac. The proposed chromatographic method has been developed using a safe and environmental‐friendly organic solvents for the concomitant stability study of thiocolchicoside and aceclofenac. The analytical risk assessment was carried out for the identification of high‐risk analytical risk factors and analytical method performance attributes. The mixture design was applied for the design of experiments‐based response surface modeling of high‐risk analytical risk factors and analytical method performance attributes. The degradation products were isolated and characterized using infrared, nuclear magnetic resonance, and mass spectral data. The proposed method was compared for its validation efficiency, greenness power, and cost‐efficiency with published chromatographic methods using the red, green, and blue models. The white score of the proposed and reported method was calculated by averaging the red, green, and blue scores of the methods. The proposed method was found to be robust, green, and economical for the concomitant stability study of thiocolchicoside and aceclofenac.

Publisher

Wiley

Subject

Filtration and Separation,Analytical Chemistry

Reference39 articles.

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3. Indian Pharmacopoeia.Volume I Residual Solvents the Indian Pharmacopeia Commission.2018.

4. DoE-Based Analytical Quality Risk Management for Enhanced AQbD Approach to Economical and Eco-Friendly RP-HPLC Method for Synchronous Estimation of Multiple FDC Products of Antihypertensive Drugs

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