Flavonoids of HerbaEpimediiEnhances Bone Repair in a Rabbit Model of Chronic Osteomyelitis During Post-infection Treatment and Stimulates Osteoblast Proliferation inVitro

Author:

Shou Dan1,Zhang Yang2,Shen Lifeng3,Zheng Rongzong4,Huang Xiaowen2,Mao Zhujun2,Yu Zhongming2,Wang Nani2,Zhu Yan1

Affiliation:

1. Department of Chemistry, Xixi Campus; Zhejiang University; Hangzhou 310028 Zhejiang China

2. Department of Medicine; Zhejiang Academy of traditional Chinese Medicine; Hangzhou 310007 Zhejiang China

3. Department of Orthopaedic Surgery; Tongde Hospital of Zhejiang Province; Hangzhou 310012 Zhejiang China

4. Department of Orthopaedic Surgery; Lishui Central Hospital; Lishui 323000 Zhejiang China

Funder

National Natural Science Foundation of China

Zhejiang Provincial Medical and Health Science and Technology Fund

Science and technology project of Zhejiang Province

Publisher

Wiley

Subject

Pharmacology

Reference28 articles.

1. Global signatures of protein and mRNA expression levels;Abreu;Mol Biosyst,2009

2. Osteoblast isolation from murine calvariae and long bones;Bakker;Methods Mol Med,2003

3. IL-6 alters osteocyte signaling toward osteoblasts but not osteoclasts;Bakker;J Dent Res,2014

4. Total flavonoid fraction of the Herba epimedii extract suppresses urinary calcium excretion and improves bone properties in ovariectomised mice;Chen;Br J Nutr,2011

5. TGF-β and BMP signaling in osteoblast differentiation and bone formation;Chen;Int J Biol Sci,2012

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