Affiliation:
1. Department of Clinical Medicine, School of Medicine Hangzhou City University Hangzhou China
2. Key Laboratory of Novel Targets and Drug Study for Neural Repair of Zhejiang Province, School of Medicine Hangzhou City University Hangzhou China
Abstract
AbstractThe N‐methyladenosine (m6A) modification of ribosomal RNA (rRNA) plays critical roles in regulating the function of ribosomes, the essential molecular machines that translate genetic information from mRNA into proteins. Specifically, m6A modification affects ribosome biogenesis, stability, and function by regulating the processing and maturation of rRNA, the assembly and composition of ribosomes, and the accuracy and efficiency of translation. Furthermore, m6A modification allows for dynamic regulation of translation in response to environmental and cellular signals. Therefore, a deeper understanding of the mechanisms and functions of m6A modification in rRNA will advance our knowledge of ribosome‐mediated gene expression and facilitate the development of new therapeutic strategies for ribosome‐related diseases.
Funder
National Natural Science Foundation of China
Natural Science Foundation of Zhejiang Province
Subject
Cell Biology,Clinical Biochemistry,General Medicine,Biochemistry