Affiliation:
1. Chemical Research Department APL Research Centre‐II, Aurobindo Pharma Limited Hyderabad Telangana India
2. Department of Engineering Chemistry, A. U. College of Engineering (A) Andhra University Visakhapatnam Andhra Pradesh India
Abstract
ABSTRACTThe present article discloses an improved, efficient, and simple resolution methodology for the preparation of (S)‐benoxaprofen which is a nonsteroidal anti‐inflammatory drug (NSAID). The resolution of racemic benoxaprofen uses an easily available, efficient, recoverable, and cost‐effective chiral reagent, namely, (1R,2S)‐(+)‐cis‐1‐amino‐2‐indanol. This novel resolution process is having a very high purity of (S)‐benoxaprofen, greater than 99%, substantially free from (R)‐benoxaprofen (less than 1%).
Reference13 articles.
1. Mechanisms of Damage to the Gastrointestinal Tract From Nonsteroidal Anti-Inflammatory Drugs
2. E.Delme P.Chalfont andW. D.David C.Terence A. H.Farnborough “Benzoxazole Derivatives ” (1978) United States Patent RE 29 608.
3. V.AlbertoandS.Roberto “Process for Preparing 2(4‐Fluorophenyl)alpha‐methyl‐5‐benzoxazole Acetic Acid ” (1987) United States Patent 4 652 654.
4. A concise enantioselective total synthesis of (+)-epi-muricatacin, using asymmetric hydrogenation/intramolecular iodoetherification as key steps