Biomarker‐driven phenotyping in Parkinson's disease: A translational missing link in disease‐modifying clinical trials

Author:

Espay Alberto J.1,Schwarzschild Michael A.2,Tanner Caroline M.3,Fernandez Hubert H.4,Simon David K.5,Leverenz James B.6,Merola Aristide1,Chen‐Plotkin Alice7,Brundin Patrik8,Kauffman Marcelo A.9,Erro Roberto1011,Kieburtz Karl12,Woo Daniel13,Macklin Eric A.14,Standaert David G.15,Lang Anthony E.16

Affiliation:

1. Department of NeurologyUC Gardner Neuroscience Institute, Gardner Center for Parkinson's disease and Movement Disorders, University of CincinnatiCincinnati Ohio USA

2. MassGeneral Institute for Neurodegenerative Disease, Department of NeurologyMassachusetts General HospitalBoston Massachusetts USA

3. Department of NeurologyUniversity of California–San Francisco and the Parkinson's Disease Research Education and Clinical Center, San Francisco Veterans Affairs Medical CenterSan Francisco California USA

4. Center for Neurological Restoration, Cleveland ClinicCleveland Ohio USA

5. Department of NeurologyBeth Israel Deaconess Medical Center and Harvard Medical SchoolBoston Massachusetts USA

6. Lou Ruvo Center for Brain Health, Neurological Institute, Cleveland ClinicCleveland Ohio USA

7. Department of NeurologyPerelman School of Medicine at the University of PennsylvaniaPhiladelphia Pennsylvania USA

8. Center for Neurodegenerative Science, Van Andel Research Institute, Grand RapidsMichigan USA

9. Consultorio y Laboratorio de Neurogenética, Centro Universitario de Neurología “José María Ramos Mejía” y División Neurología, Hospital JM Ramos Mejía, Facultad de Medicina, UBA, and Programa de Medicina de Precision y Genomica Clinica, Instituto de Investigaciones en Medicina Traslacional, Facultad de Ciencias Biomédicas, Universidad Austral‐CONICETPilar Argentina

10. Sobell department of Motor Neuroscience and Movement DisordersUniversity College London, Institute of NeurologyLondon United Kingdom

11. Department of NeuroscienceBiomedicine and Movement Science, University of VeronaVerona Italy

12. Department of Neurology and CHETUniversity of Rochester Medical CenterRochester New York USA

13. Department of Neurology and Rehabilitation MedicineUniversity of Cincinnati Medical CenterCincinnati Ohio USA

14. Department of MedicineBiostatistics Center, Massachusetts General HospitalBoston Massachusetts USA

15. Center for Neurodegeneration and Experimental Therapeutics, Department of NeurologyUniversity of Alabama at BirminghamBirmingham Alabama USA

16. Morton and Gloria Shulman Movement Disorders CenterToronto Western Hospital and The Edmond J. Safra Program in PD, Toronto, Ontario, Canada, University of TorontoToronto Ontario Canada

Publisher

Wiley

Subject

Clinical Neurology,Neurology

Reference26 articles.

1. Precision medicine for disease modification in Parkinson disease

2. The ongoing pursuit of neuroprotective therapies in Parkinson disease

3. Disease-Modifying Drugs in Parkinson’s Disease

4. The neuromythology of Parkinson's Disease

5. I. A clinical and histological study of certain adenocarcinomata of the breast: and a brief consideration of the supraclavicular operation and of the results of operations for cancer of the breast from 1889 to 1898 at the Johns Hopkins Hospital;Halsted WS;Ann Surg,1898

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